Clinical Improvement and Prolonged Survival With High Dose Intrathecal Methotrexate for Carcinomatous Meningitis Secondary to a Lung Adenocarcinoma
نویسندگان
چکیده
Carcinomatous meningitis (CM) is a devastating complication of advanced cancers. No standard treatment is available for CM secondary to solid tumors. In particular, very few data have been published for CM related to lung adenocarcinoma. Herein we report the case of a 39-year old woman treated for a metastatic lung adenocarcinoma, without EGFR mutation, complicated by a CM. Intrathecal administrations of high dose methotrexate produced both a clinical improvement of symptoms related to CM and an unusually delayed survival.
منابع مشابه
Carcinomatous Meningitis: The Natural History of Successfully Treated Metastatic Bladder Cancer
Carcinomatous meningitis due to bladder cancer is a rare entity reported only in case reports. Optimal therapy is thus poorly defined with earlier cases reporting an unsuccessful outcome. Here we report a case of late carcinomatous meningitis secondary to transitional cell carcinoma (TCC) of the bladder occurring in a patient in complete remission. He was successfully treated with intrathecal m...
متن کاملIntrathecal Methotrexate and Craniospinal Radiotherapy Can Be an Effective Treatment of Carcinomatous Meningitis in Patients with Breast Cancer: Case Reports
INTRODUCTION Carcinomatous meningitis in breast cancer occurs as a complication in up to 5% of all cases. It is a very devastating diagnosis, with a median patient survival of about 3 months. Treatment is very controversial, and different modalities of treatment have been used but none of them show significant benefit for overall survival. CASE REPORTS We report 2 cases of carcinomatous menin...
متن کاملRecovery from carcinomatous meningitis by erlotinib.
Treatment options include whole-brain irradiation, systemic chemotherapy, and intrathecal chemotherapy such as methotrexate [2]. Despite these measures, the prognosis is poor with a median survival of 2–3 months, and focal neurologic dysfunctions do not improve in most cases [1]. The benefit of EGFR tyrosine kinase inhibitors (TKIs) in the treatment of carcinomatous meningitis in patients with ...
متن کاملComparison of CNS Relapse, Survival and Intelligent Quotient in Non-High Risk ALL Children Treated with Intrathecal Methotrexate or Triple Intrathecal Therapy
Background Compared to intrathecal methotrexate (IT MTX), triple intrathecal therapy (TIT) has shown promising results in decr...
متن کاملCarcinomatous meningitis complicating carcinoma of uterine cervix: an uncommon presentation
Carcinomatous meningitis is a rare clinical entity associated with gynaecological malignancies. However, it is an unusual occurrence in carcinoma of uterine cervix. Here we report a case of a 55-year-old female who was diagnosed to have carcinoma of uterine cervix stage IIB and was started on radiotherapy to whole pelvis with curative intent. One week later she complained of sudden onset of hea...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2011